New Sun Cream Compound Provides Protection On Cellular Level

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A sun cream compound developed by scientists from the University of Bath in London, together with scientists from King’s College in London, is able to provide a high level of screening protection against the harmful radiation from sunlight.

Sun Cream Compound like no other

Unlike skin surface protection offered by traditional sunscreen and sun blocks this new discovery called the mitoiron claw, works more than just a skin lotion. It offers deep protection within the cellular level and isolates the effect within the UVA affected cell, without harming the rest of the cell.

The researchers are hoping that the mitoiron claw compound may soon become an ingredient incorporated into sunscreens and other skin care products in the next 3 to 4 years.

The mitochondria, which provides the cells with energy, has very high free iron concentrations and is crucial for many vital functions in the body. But when exposed to UVA in sunlight, excess free irons act as a catalyst that spurs the production of toxic reactive oxygen species or ROS. It can cause damage to cell components like DNA, fat and proteins increasing the risk of cellular death and even cause cancer.

With this special customized iron chelator, it moves directly into the mitochondria and safely binds the excess free iron to prevent it from reacting when exposed to UVA rays.

Initial tests shows promising results

When tests were done with human skin fibroblast cells that wwere exposed to UVA, radiation, it showed that cells treated with the mitoiron claw were protected from dying, while the untreated ones showed cell death.

 “The role of iron-mediated damage induced upon exposure of skin cells to UVA has been underestimated for many years. For efficient protection against UVA-induced iron damage of skin strong chelators are needed, but until now these risked toxic effects caused by non-targeted iron starvation of cells”, says Dr Charareh Pourzand of the Department of Pharmacy and Pharmacology of the University of Bath.

“Our mitochondria-targeted compound provides a solution to this problem and can address an unmet need in the skincare and sunscreen fields. This mitoiron claw is a highly effective compound, offering unprecedented protection against UVA-induced mitochondrial damage.”, Pourzand added.

The researchers also points out they are hoping that ongoing research would be able to identify more uses of this new compound, but hopes that they may soon be able to see their work help ease skin problems, including skin cancer, all over the world.

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